Setanaxib GKT137831
GKT137831
CAS: 1218942-37-0
Molecular Formula: C21H19ClN4O2
Setanaxib GKT137831 - Names and Identifiers
Setanaxib GKT137831 - Physico-chemical Properties
| Molecular Formula | C21H19ClN4O2 |
| Molar Mass | 394.85 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Boling Point | 560.5±60.0 °C(Predicted) |
| Solubility | DMSO: ≥ 37 mg/mL |
| Appearance | solid |
| Color | Pale yellow |
| pKa | 5.13±0.25(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| In vitro study | In HPAECs and HPASMCs, GKT137831 attenuated hypoxia-induced H(2)O(2) release, cell proliferation, and TGF-β1 expression, and improved PPARγ expression reduction. In human artery endothelial cells, GKT137831 also protects against oxidative stress in response to hyperglycemia. |
| In vivo study | In WT and SOD1 Mut mice, GKT137831 (60 mg/kg I. g.) blocked liver fibrosis and downregulated oxidative stress, inflammation, and fibrosis. GKT137831 (60 mg/kg/d p.o.) it also attenuates long-term hypoxia-induced right ventricular hypertrophy, vascular remodeling, lung cell proliferation, and changes in lung PPARγ and TGF-β expression under hypoxia. In diabetic apolipoprotein E-deficient mice, GKT137831 (60 mg/kg/d p.o.) attenuates diabetic accelerated atherosclerosis. In addition, in c-hNox4Tg mice injected with Ang II, GKT137831 abolished the increase in oxidative stress, inhibited Akt-mTOR and NF-κB signaling pathways, and attenuated cardiac remodeling. |
Setanaxib GKT137831 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.533 ml | 12.663 ml | 25.326 ml |
| 5 mM | 0.507 ml | 2.533 ml | 5.065 ml |
| 10 mM | 0.253 ml | 1.266 ml | 2.533 ml |
| 5 mM | 0.051 ml | 0.253 ml | 0.507 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: GKT137831 Visit Supplier Webpage Request for quotationCAS: 1218942-37-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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